PPARγ regulated CIDEA affects pro-apoptotic responses in glioblastoma
نویسندگان
چکیده
منابع مشابه
The synthetic ligand of PPARγ ciglitazone affects human glioblastoma cell lines
c) The number of text pages, number of tables, figures, and references, and the number of words in the Abstract, Introduction and Discussion (each item should be placed on a separate line) Text pages: 33 Number of tables: 1 Number of figures: 8 Number of references: 40 Number of words in the Abstract: 249 Number of words in the Introduction: 669 Number of words in the Discussion: 1 484 d) A lis...
متن کاملRoscovitine has anti-proliferative and pro-apoptotic effects on glioblastoma cell lines: A pilot study.
Purine analogue roscovitine, a cyclin-dependent kinase (CDK) inhibitor, has shown strong anti-proliferative and pro-apoptotic effects in solid and hematologic cancers such as non small-cell lung cancer and lymphomas. It targets CDK2, 7 and 9 preferentially, which are also overexpressed in glioblastoma. Τherefore, the biological effects of roscovitine in glioblastoma cell lines were investigated...
متن کاملBiological Rationale for the Use of PPARγ Agonists in Glioblastoma
Glioblastoma multiforme (GBM) is the most common primary intrinsic central nervous system tumor and has an extremely poor overall survival with only 10% patients being alive after 5 years. There has been interesting preliminary evidence suggesting that diabetic patients receiving peroxisome proliferator-activated receptor gamma (PPARγ) agonists, a group of anti-diabetic, thiazolidinedione drugs...
متن کاملThiamine deficiency activates hypoxia inducible factor-1α to facilitate pro-apoptotic responses in mouse primary astrocytes
Thiamine is an essential enzyme cofactor required for proper metabolic function and maintenance of metabolism and energy production in the brain. In developed countries, thiamine deficiency (TD) is most often manifested following chronic alcohol consumption leading to impaired mitochondrial function, oxidative stress, inflammation and excitotoxicity. These biochemical lesions result in apoptoti...
متن کاملIn-vitro Apoptotic Effects of Deferoxamine on the Glioblastoma Cell Line
Background: Research suggests the inhibitory effects of deferoxamine as an iron chelator on erythroleukemia cells. The present study was conducted to investigate the effects of deferoxamine on B92 cells as a model of glial cells carcinoma. Materials and Methods: The present experimental study treated 6×104 B92 cells with 0, 10, 50 and 100 µM of deferoxamine for 24 hours in the presence or absen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Death Discovery
سال: 2015
ISSN: 2058-7716
DOI: 10.1038/cddiscovery.2015.38